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+--- Thread: Run 16-bit game without a virtual machine, it is possible (/showthread.php?tid=14112)
Run 16-bit game without a virtual machine, it is possible - GethN7 - 04-07-2021
https://github.com/otya128/winevdm
This is basically Wine for 64-bit Windows.
64-bit Windows can't run those retro Windows 3.x games because 64-bit processors don't support 16-bit instructions. The above effectively acts as an on the fly compatibility layer that patches in 32-bit code for 16-bit code so 16-bit stuff will work normally in 64-bit Windows.
Screenshot with proof attached.