One Naruto/ME cross that might be interesting would be if the planet the Normandy crashes on post ME3 was ninja world - put the ME characters into Naruto, in other words, rather than the other way around as usually happens. Why? Because a handful of high-tech users in a low-tech world has a number of interesting plot lines open, while low-tech characters in a space opera setting are basically in a race to get acclimated and scavenge space armor and pewpew lasers before they get killed from beyond the threat radius they understand. This does of course mean you get no Sheppard, but surely there's enough interesting characters in the party to tell some interesting stories even without her. Or him.
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"Anko, what you do in your free time is your own choice. Use it wisely. And if you do not use it wisely, make sure you thoroughly enjoy whatever unwise thing you are doing." - HymnOfRagnorok as Orochimaru at SpaceBattles
woot Med. Eng., verb, 1st & 3rd pers. prsnt. sg. know, knows
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"Anko, what you do in your free time is your own choice. Use it wisely. And if you do not use it wisely, make sure you thoroughly enjoy whatever unwise thing you are doing." - HymnOfRagnorok as Orochimaru at SpaceBattles
woot Med. Eng., verb, 1st & 3rd pers. prsnt. sg. know, knows