Hm... I started to have an idea for an all-out Serenity/SM fusion (aboard the Firefly-class ship Princess Serenity), where "Earth-that-was" was the Silver Millenium, but it started to come apart at the seams.
Mamoru/Mal: the hardened anti-hero, haunted things what he remembers (and what he doesn't, entirely)
Rei/Zoe: A damn near perfect fusion -- she and Malmoru tried a fling, once, but while it didn't pan out it left them solidly on friendly terms.
Inara/Usagi: This could actually work -- they both have the biggest hearts in their respective series...
Kaylee/Ami: hm, maybe? Would that make Simon Urawa?
Makoto/Jayne: Um, I dunno, I have problems with this.
River/Hotaru: that could work, but would it mean that Simon is Haruka? And where's michiru?
Setsuna/Book: a bad fit, but where else could you put Pluto?
Conspicuously missing: Minako (off in "England"?) and Michi. Also, who do you fuse Wash with? Umino is the first person that comes to mind, but that means that Naru... well, maybe Nephrite doesn't die this time... ARGH.
Mamoru/Mal: the hardened anti-hero, haunted things what he remembers (and what he doesn't, entirely)
Rei/Zoe: A damn near perfect fusion -- she and Malmoru tried a fling, once, but while it didn't pan out it left them solidly on friendly terms.
Inara/Usagi: This could actually work -- they both have the biggest hearts in their respective series...
Kaylee/Ami: hm, maybe? Would that make Simon Urawa?
Makoto/Jayne: Um, I dunno, I have problems with this.
River/Hotaru: that could work, but would it mean that Simon is Haruka? And where's michiru?
Setsuna/Book: a bad fit, but where else could you put Pluto?
Conspicuously missing: Minako (off in "England"?) and Michi. Also, who do you fuse Wash with? Umino is the first person that comes to mind, but that means that Naru... well, maybe Nephrite doesn't die this time... ARGH.