I'm pretty sure they are created during install, so I don't think you'll get things to stop making them. I know that NWN2 and Mass Effect have their user-specific/generated content like saves and screenies (and the override dir for mods) in the My Documents section. So some you can't just delete it and keep it gone. You might, though, as Ira suggests, be able to redirect them somewhere else and delete the current folder. I'm not sure how successful this will be, though. Suffice it to say, it is not going to be a recommended practice.
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The Master said: "It is all in vain! I have never yet seen a man who can perceive his own faults and bring the charge home against himself."
>Analects: Book V, Chaper XXVI
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The Master said: "It is all in vain! I have never yet seen a man who can perceive his own faults and bring the charge home against himself."
>Analects: Book V, Chaper XXVI