Well, Giant Monsters will still die. I even helped kill a couple (Deathsurge and Jurassik) when GMs still had the sick buff that got toned down recently. It was tough, though, Deathsurge in particular likes to run away when you start hurting him.
You just absolutely have to have someone debuffing their health regeneration, hopefully more than one. Even with their regen toned down, they have so many HP that they heal at Ludicrous Speed. So Rads, Kinetics, Darks, and /Cold Corrupters are In Demand(tm) for Giant Monsters and AVs. (Though Twilight Grasp doesn't have -Regen in it's description, it definitely has the same visual effect as other -Regen powers and seems to have the same anti-target-heal effect as well. The general consensus seems to be that it's just mislabelled.)
A team I was on with my newly-50 scrapper was having a lot of trouble with some AVs even though we had a Kinetics defender on the team. I don't think the player realized that their basic heal had -regen in it, though. I asked them to start spamming Transfusion in between Smites and Shadow Mauls (it came out as "spam Transfusion on Baphomet, PLEASE!!"), and once they started that, we took him down in short order, and several more AVs in missions after that. I explained about the -regen after Baphy went down. "Broad-minded is just another way of saying a fellow's too lazy to form an opinion." -- Will RogersGlobal: @Jimmy Amp
"Broad-minded is just another way of saying a fellow's too lazy to form an opinion." -- Will Rogers
You just absolutely have to have someone debuffing their health regeneration, hopefully more than one. Even with their regen toned down, they have so many HP that they heal at Ludicrous Speed. So Rads, Kinetics, Darks, and /Cold Corrupters are In Demand(tm) for Giant Monsters and AVs. (Though Twilight Grasp doesn't have -Regen in it's description, it definitely has the same visual effect as other -Regen powers and seems to have the same anti-target-heal effect as well. The general consensus seems to be that it's just mislabelled.)
A team I was on with my newly-50 scrapper was having a lot of trouble with some AVs even though we had a Kinetics defender on the team. I don't think the player realized that their basic heal had -regen in it, though. I asked them to start spamming Transfusion in between Smites and Shadow Mauls (it came out as "spam Transfusion on Baphomet, PLEASE!!"), and once they started that, we took him down in short order, and several more AVs in missions after that. I explained about the -regen after Baphy went down. "Broad-minded is just another way of saying a fellow's too lazy to form an opinion." -- Will RogersGlobal: @Jimmy Amp
"Broad-minded is just another way of saying a fellow's too lazy to form an opinion." -- Will Rogers